How Immunology Saves a Life

ShidoDesu @ Youtube

Legenda: Camisola Vermelha - Patogénios
Camisola Branca - (geralmente) Macrófagos
Camisola Preta - Linfócitos T

Letra:
Step one, you step on a sharp rock
You say oh well, it left such a small mark
But just that little bit of rust
Resulted in acquiring Tetanus
Onset of this of this infection caused macrophage activation
NF-kB made IL 1, 6, and TNFa you begin to wonder why fever came.
What a poor defense, I'm feeling sick
Redness, swelling and tenderness
And I would have cleared it by now, abated
Had I been vaccinated
DC TLR 5 liked flagellin
And TLR 4 was LPS stalkin'
Try to slip past its defense
But antigens aren't innocent
Travel down the lymph nodes in a throng B seven signals growing strong
And pray that T cells miss you
Yeahhhh, pray that T cells miss you
Why's this bond so strong, CD28
Costimulated and I just can't wait
To proliferate, differentiate
T-cells know how to save a life
As CD8 T-cells leave this place It's finally time to make just one last choice
TH1 with IFN Or TH2, IL-4 secretion?
He will do one of two things
He will support the macrophage
Or he'll play the B cell's game
CD40L will express all the same
B cells secrete IgM and D recognizes the pathogen
AID help to class switch to IgG Somatic Hypermutation
Complex forms between Ab-Ag
Complement flows surreptitiously
Punctures the membrane with all of its might
And attracts lots of phagocytes
I fell on to a knife
Let's do this one more time
Secondary response, I've got a friend
Plasma, antibodies, and memories
Soon I will clear this disease
Memory response, I do a dance
Damn pathogens don't stand a chance
And now I will stay up with you all night
Because my final is at 9...
A parking, I'll take the fine
If only I had more time

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